20. A PLASTIC TSUNAMI ENTERING HUMAN BODIES

Courtesy Greenpeace, plastic in Kinshasa

Dear reader,

Summary: We consume more plastics than we think. Especially the smallest particles, the Nanoplastics, can have a bad effect on your long-term health. Science is working hard, much is still unclear, but signs are not good. Try to limit your contact with plastic significantly. Avoid using plastic bottles, plastic coffee and tea cups and chewing gum. See point 8 how to minimise your exposure to these plastic particles.

  1. Research only at its infancy/I am worried

I know research is ongoing and final conclusions will take years, but doesn’t this micro and nanoplastic stuff sound scary? Plastics might sound innocuous, but there are many types, some of which can cause cancer or other diseases. 

The effect of all these micro- and Nanoplastics entering our bodies is still unknown. The more I read, the more concerned I become. Plastics are a holistic concept, but when you break them down you enter a world dangerous additives. You also read about Nanoplastics as molecular pollutants that attach to fungus, algae and bacteria.

Writing this blog did not help, nor did these alarming headlines: “0.5% of the brain consists of Nanoplastics,” “Nanoplastics found in penises,” and “Nanoplastics entering individual cell structures.”

2, Most experts downplay the risk,

Experts claim that the public is overreacting. A quarter of the Dutch population believes that microplastics, and especially Nanoplastics, are among the top dangers to one’s health. The Dutch are perhaps exaggerating, but probably not. From what I have read this plastic future does not look all too good.

We do not know what interaction might occur between these smallest particles and living organisms. The idea that the tiniest particles can enter your individual cells is worrying. In reality, they do enter your cells. The increasing amount of plastic found in people’s brains is also not a good sign.

Dear reader, I don’t know about you. I am truly concerned. There seems to be no end to the plastic tsunami that overwhelms us. This news from the Netherlands is a bit off topic but related. It states that eggs from free-ranging chickens are too dangerous to eat. Can you imagine? Apparently, there is so much poison in the Dutch soil that it impacts the quality of food the chicken eat. This, in turn, affects the quality of the eggs.

There are actions we can take, such as avoiding these contaminated eggs. Or, in the case of plastics, minimizing their use as much as possible. Below are some tips in this blog.

For everything else, we must keep an eye on scientific developments.

3. Ok, what are micro plastics and Nanoplastics?

Microplastics are small plastic particles. They are usually defined as being less than 5 millimeters in size. However, they can be much smaller. They originate from the breakdown of larger plastic debris, like bottles and bags. They also include fragments of stabilizers, lubricants, fillers, and plasticizes. Manufacturers use these and other chemicals to impart desirable properties to plastics. Such properties include transparency, flexibility, and durability. Many of these chemicals have been classified by experts as toxic and harmful to human health.

Microplastics are widespread in the environment, found in oceans, waterways, soil, and even in the air. They pose increasing environmental challenges. Microplastics contaminate ecosystems and enter food chains, such as in fish. Animals and humans can ingest them, potentially causing harm over time.

Nanoplastics (sometimes calles nanoparticles, but this is a wider concept) are particles less than 100 nanometers in size. This size is less than 1/10,000 of a millimeter. They are much smaller than microplastics and more concerning because they can overcome certain barriers and enter human cells. They can be purposefully engineered in various scientific and industrial processes. For example, they are used for materials like carbon nanotubes. Alternatively, they may occur naturally in some processes. They can also result from the further breakdown of microplastics.

4. Just some plastic statistics

In 2020, approximately 367 million tons of plastics were produced worldwide. This amount is almost double that of 2000, which had an annual production of 200 million tons. Production is still growing on an annual basis.

Researchers estimate that the average person consumes between 78,000 and 211,000 microplastic particles every year. Plastic-based bottled water has a big role in these figures. Hot drinks in plastic cups can also contribute significantly. Together, they can make up to 50% of the intake. And remember, we talk about the micro plastics, the “big” particles, up to half a centimeter! every year through drinking water, foods contaminated by microplastics, and breathing microplastics-containing air. The number of Nanoplastics is infinitively more and can be 200.000 in one plastic bottle with water.

Fortunately, most, but not all leaves our body again the natural way.

In early 2024, a new study revealed that human brain samples collected at autopsy contained significantly more plastic. They had seven to 30 times more plastic than the kidneys and liver. Compared to 2016, this concentration represents about a 50% increase, indicating that, as of today, about 99.5% of the brain is brain tissue and the rest is plastic.

5. Not only plastic bottles and plastic coffee cups are of concern. Chewing gum as well.

A pilot study presented at the American Chemical Society’s spring 2025 meeting revealed that chewing gum can release hundreds to thousands of micro and nano plastic particles into saliva, which are then potentially ingested.

6. Dangers of micro- and nanoplastics

Microplastics and Nanoplastics have infiltrated ecosystems worldwide and have been detected in air, water and soil. Their small size allows them to enter the human body through ingestion, inhalation and dermal contact. Chemical additives like polychlorinated biphenyls and phthalate esters are added to microplastics during production. These additives typically exacerbate health effects. Microplastics are therefore recognized as an emerging environmental concern. They are also a public health concern. These concerns have the potential to affect both human well-being and the natural environment.

The much smaller parts, the Nanoplastics, can penetrate biological barriers. They enter cells and tissues, raising concerns about long-term health effects. It alarms me to learn that microplastic and nano plastic concentrations in brain samples are seven to 30 times higher. These concentrations are notably higher than those in kidneys and liver. As always with relative new developments, more studies need to be done to understand what the health implications are.

The mechanisms by which Nanoplastics enter the brain remain unclear. One hypothesis is that they travel with lipids ingested through food. Human brains are particularly rich in fat, which may help plastics cross the blood-brain barrier. Inhalation of airborne microplastics and ingestion through diet are considered primary routes of exposure.

7. Just one example how plastic pollution originates and affects us all

Biosolids, which are the treated water sludge generated from wastewater treatment, significantly contribute to plastic pollution in terrestrial environments. They are commonly utilized as fertilizers in agricultural land. This practice results in a considerable deposition of microplastics onto farmlands. In Europe, estimates vary between 63,000 to 430,000 tons of microplastics are deposited annually. In North America, the range is 44,000 to 300,000 tons. Consequently, agricultural soils serve as extensive reservoirs of microplastics. These particles are transported to the aquatic environment through various means. These means include rainfall, leaching, and irrigation.

8. First suspected links with diseases

There is ongoing debate over the health impacts of these microplastics within human tissues. These risks encompass inflammation, oxidative stress, and tissue damage. They have been found in vital organs such as the heart, liver, lungs, and even placenta. 

One study also found that individuals with dementia have more plastic fragments in their brains. The amount is three to five times higher than those without the condition. It was noted that dementia can impair the blood-brain barrier and brain clearance mechanisms, possibly creating a “sink” for plastics. Again, no definitive proof yet.

Some experts argue that nano plastics carry harmful chemicals. These chemicals are known to lead to reproductive issues. They cause hormonal imbalances by disrupting the endocrine function.

There appears to be a link between plastics and obesity.

9. What to do?

Summary: reducing exposure to microplastics and nano particles involves several lifestyle and consumer choices. Below some suggestions I summarized from reliable sources on internet.chapter

My own top 5 is: never heat anything in plastic, avoid drinks from plastic bottles (= no 1 tip), do not drink hot drinks from plastic, store in metal or porcelain, repack from plastic in metal, glass or porcelain, not cutting food on plastic cutting-board. I cut everything on an ordinary porcelain plate. And stop chewing gum.

Suggestions from internet

Filtering and boiling water.

Cutting back on plastic use when possible, for example, by using reusable containers

Boosting fiber intake involves two types of fiber. Fermentable fiber found in fruits and vegetables forms a gel-like substance in your gut. This helps trap microplastics and prevents them from entering your system. Meanwhile, non-fermentable fiber helps push these harmful particles through your digestive tract. It does this before they can be absorbed. In a world where microplastics are unavoidable, fiber could be your best defense

Not using single-use plastic over and over.

Avoiding heating plastic food packaging, as plastic particles can spread into the food.

Focusing on good sources for our food is essential. We should ensure our seafood is from sources that have less microplastics, for example.

Avoid foods that are ultra-processed, as there have been some reports of MNPs (=micro and nano plastics) in ultra-processed food.

Wearing natural fiber clothing — organic cotton or hemp — and avoiding those with synthetic fibers.

Vacuuming our homes more often, as microplastics can accumulate in household dust.

Being careful of environmental pollutants as high air pollution areas might have more MNPs in air.

Making sure our environment at home or work has a good air ventilation system.

This was a difficult blog to write. Too little is known about this topic, but from what we know one can only draw one conclusion: stay away as much as possible from plastics, but this will be hard to do.

Robert, your health friend,

traffic in Kinshasa, DRC. On a quiet day

21. SPERMIDINE: THE ZOMBIE CELL KILLER (health project99+)

Pelicans in the Caribbean

Before writing about the next specific supplement (spermidine), allow me to describe my vision. As always, I will explain the place of supplements in the whole chain of life-improving and extending measures.

1.Introduction

You have the big five. I do not mean  the African safari animals, but the five groups of interventions that are important for longevity. The big five for longevity are food/drinks, stress, sleep, exercise and social life. Do these five well, and you increase your chances for a longer and more healthy life. You will especially boost your chances for a much longer healthy lifespan. Do not underestimate the importance of this last point. Studies indicate that more than half of the people above 60 in the Western world face serious health problems. These issues prevent them from enjoying the remaining 20+ years of their life as they should and could.

2. Potential of supplements in general

So what about supplements? The so-called 6th wheel on the wagon. Some supplements are there to reinforce the good work within the big 5. Some are often useless, like vitamin C or Omega-3. However, other supplements offer hope. Hope for a much longer life. Many studies are ongoing and life is too short to await the results of all of them. Promising results are coming in in an accelerating way, also thanks to AI. I am one of those who is open to taking certain supplements. Their claimed effects are not yet scientifically proven. I follow the no-harm principle and go for it. 

Earlier I write about two lesser-known supplements that give me much hope: berberine and fisetin. Fisetin might add 10 – 40% to the lifespan and improve health quality as well. It also mimics the effects of intermitted fasting. Berberine supports blood sugar management and its other potential benefits. It interests me mainly because it may slow aging. It could extend life expectancy by years, not just months.

This time I write about spermidine, a supplement I take once daily (5 mg).

3. What is spermidine?

Spermidine is present in all organisms, including plants, animals, and microorganisms. In humans, it can be obtained from dietary sources such as whole grains, soy products, aged cheese, and mushrooms. Other sources include legumes and certain fruits and vegetables. It is also synthesized endogenously in the body.

4. Its name? Yes, indeed

The name “spermidine” originates from its discovery in semen. Spermidine is a polyamine compound that was first extracted from seminal fluid, which led to its name. The Latin word “sperma” means semen. “Spermidine” was named this way because it was initially identified as a significant component in sperm cells.

5. Spermidine: I go for autophagy

Spermidine is a longevity agent in mammals due to various mechanisms of action, which are just beginning to be understood. It is a naturally occurring polyamine compound found widely in living cells. It stabilizes DNA and facilitates protein synthesis. These actions make it essential for maintaining cellular functions.

The claims about spermidine are manifold; for me the most appealing part is the role it plays in autophagy. Autophagy is a cellular process that involves the degradation and recycling of damaged cellular components, helping to maintain cellular health. Spermidine may contribute to improved cellular function by promoting autophagy. This improvement could play a role in slowing down the aging process. It may also potentially increase lifespan. I am all in favor of this!

It is not only autophagy what spermidine influences. Research suggests that by promoting autophagy, spermidine might contribute to increased lifespan and cardiovascular health. It may also offer neuroprotection, including cognitive function, and metabolic health. More human studies are needed to confirm these effects. There is also evidence found for impact on other mechanisms. These include inflammation reduction, lipid metabolism, and regulation of cell growth and proliferation. 

6. What are polyamines?

Polyamines are organic compounds characterized by having two or more amino groups. They are essential for cellular functions and are found in all living organisms. The most common polyamines in biological systems are putrescine, spermidine, and spermine.

7. Why take spermidine?

Your body produces spermidine and food provides it as well. However, as we age, the body’s ability to synthesize spermidine decreases. This reduction may contribute to some age-related cellular and physiological changes. This decline is part of why researchers are looking into spermidine supplementation. They are exploring dietary sources to promote healthy aging. These sources may support cellular health. For me it an important reason to take this supplement with, as said, the main focus on autophagy. “Clean those dead cells” is a slogan that appeals to me. I am very willing to take the necessary supplements.

8. Spermidine uses in treatment of diseases.

In recent years, spermidine has attracted attention for its potential health benefits, particularly in the context of aging and longevity. Spermidine is reported to reverse the aging process and enhance cardiovascular in animal studies. Aged mice administered spermidine had healthier hearts and improvements in metabolic activities. Numerous research studies have investigated the anti-aging properties as well. Several animal studies have demonstrated that administering spermidine can aid in the prevention of certain cancers. It seems that first human studies confirm the findings of animal research.

The body’s spermidine synthesis decreases with age. It becomes progressively difficult for your body to activate autophagy without an adequate spermidine level. This contributes to aging. This can be regenerated for older adults by consuming a diet rich in spermidine or, more effectively, by taking supplements. Synthetic spermidine mimics the naturally occurring molecules in every way. 

9. Side Effects? 

Because spermidine is a naturally occurring substance in the body, it is thought to be completely safe. Long trials have shown that the supplement has no adverse side effects. This is true even when taking high doses, up to 6 milligrams daily.

10. Dosage?

There is a debate among specialists about the required dosage. Global estimates of spermidine consumption range between 5 mg and 12 mg per day via dietary sources.

As mentioned spermidine is a naturally occurring polyamine found in various foods, particularly certain vegetables. Some of the vegetables with the highest spermidine content include broccoli. Cauliflower also contains a few mg per 100 grams of fresh weight of vegetables.

Dr. Sinclair takes about 1 mg of spermidine per day. I do 5 mg per day.

11. Safety

The “no-harm” approach is central to my decision to use any supplement. I take several supplements based on “hope” when there are credible indications that they might provide certain benefits. 

However, I only take supplements considered completely safe and that do not interact with any medication. This seems to be the case with spermidine, as far as I could find out. It’s important to note that what holds in animal models doesn’t always directly translate to humans. This is due to differences in physiology and dosage responses. So, more research is crucial to confirm these effects in humans.

13. Weak Points of Supplements (in general)

Supplements generally have two weak points:

1. Their production is not officially regulated or controlled by health agencies, so it’s crucial to buy from reputable companies. My advice is not to be guided by price.

2. Many health claims are not scientifically proven.

14. Which is better, NMN or spermidine?

Spermidine powder inhibits aging via autophagy, but NMN powder can have anti-aging benefits by increasing NAD+ levels in the body. Scientists suggest there may be synergistic benefits when NMN and spermidine are combined. This combination might be a potential strategy for enhancing health in elderly people. Interesting and something I follow closely.

Take care and live a happy and healthy life,

Robert, your health friend

Flamingos in the Venezuelan estado de Falcon

9. FOUR DRINKS: (C) THE EVENING VEGETABLES SOUP (health project99+)

Summary: by turning solid vegetables into soup, for six years I now easily meet my daily vegetables target. And my body is grateful for it.

1. I don’t like vegetables...

I’ve never been a fan of vegetables. I would tolerate only peas and maybe some carrots. They had to be covered in Dutch apple sauce (which is not healthy because of its high sugar content). Potatoes and especially French fries got a pass. They might count as veggies, but peeled and fried, they do not offer much health benefit.

I have known all these years, of course, that vegetables should play a starring role in any healthy diet. My mother said a thing or two about it, if I remember correctly. Willpower is essential for any lifestyle change. The motivation to eat these green, red, orange and white things was just lacking. I will write about the importance of will power (and the lack of it) in another blog.

2. But…….

About six years ago, my wife decided she’d had enough of my veggie aversion. She started making vegetable soup, using fresh or frozen vegetables only. A blend of persuasion and gentle insistence managed to get me to eat it daily. It was a brilliant move and since then, I haven’t looked back. Vegetables are now an integral part of my diet, and the numbers from my annual health tests show the benefits. *(For context, biomarkers are biological molecules that indicate normal or abnormal processes or conditions in the body.)

3. More about vegetables

I enjoy incorporating a variety of vegetables into my meals. I include red beets, broccoli, spinach, carrots, cauliflower, pumpkin, and sweet potatoes. I like to spice things up with a bit of celery or leek—I would use onions, but I’m unfortunately allergic. Instead of combining all these vegetables at once, I prefer selecting a mix that suits my needs. Not always a culinary success, by the way, but that is part of the process. Healthy they always are!

Each vegetable brings its own unique benefits. For example, beets are touted for their potential health properties, including (unproven) anti-cancer claims. Broccoli and spinach offer around 3 grams of protein per 100 grams. Sweet potatoes are particularly impressive, containing 35% fewer carbs than regular potatoes and packed with vitamins and minerals. 

All these vegetables are excellent sources of fiber which is crucial for health. Good to know as it can be challenging to consume fiber in sufficient quantities, just as it is with protein. Life is unfair because if we compare proteins and fiber with sugar, there the opposite is true. Sugar, our common dietary foe is found in many forms in our food and very easy to overeat.

One caveat. Some vegetables have a surprising amount of sugar as well, so be careful. For example, carrots contain 6 grams per 100 grams, beetroot has 8 grams, and pumpkin 5. In contrast, broccoli contains only about 0.4 grams.

4. At home we have a diet that is 3/4 liquid

A. Lemon juice to start the day and as a drink in between (1 liter). https://shakethehealthtree.com/index.php/2025/02/25/5-lemons-and-limes-health-project-99/

B. A large smoothie for breakfast and lunch (up to one liter). I already wrote about this morning routine.  https://shakethehealthtree.com/index.php/2025/03/10/9-four-drinks-a-morning-afternoon-smoothie-health-project-99/

C. A fresh soup for the evening, with some carbs and proteins like fish, 0.4 liters. 

D. Two glasses of water/lemon juice with collagen and creatine (0.5 liters), one in the morning with added protein, and one in the evening without extra protein. 

5. Carbs, meat, fish

We aren’t against carbs. They just need to come in the form of whole food. We prefer these over white bread, white rice, or light pasta. We don’t eat much meat, and when we do, it’s mainly organic chicken. We consume fish more frequently, though less than before due to a variety of increasing concerns ranging from mercury to nano-plastics. And I already wrote about the (too) big role nuts play in my diet.

6. Preparation

I mostly use frozen vegetables for their health benefits, cleanliness, practicality, and affordability. When I buy fresh, I cook and freeze them for later use.

I start by boiling approximately ½ kg of frozen vegetables. After boiling for a few minutes, I transfer everything into a blender. I then add salt, pepper, two teaspoons of olive oil, and a generous amount of herbs. Once blended, voilà—a delicious vegetable soup is ready, although not always perfect! Too much cauliflower for example is not to my taste :).

Enjoy a happy, tasty and healthy life,

Robert, your health friend

Cool guys in the DRC, when times were more peaceful